Projectile systems are provided herein employing an inhibiting and/or marking substance for impairing/marking a living target, such as a human or animal target. In preferred embodiments, the projectile system includes a generally frangible projectile that is optimally filled to at least about 50%, with the substance to be delivered to the target, such that the substance is radially dispersed into a cloud upon impact. In one implementation, the substance delivered comprises a powdered inhibiting substance, such as a powdered pepper. In one implementation, the powdered inhibiting substance comprises a substance having one or more capsaicinoids.