Hydroxamic acids having the formula ##STR00001## are useful in treating disease conditions mediated by TNF-.quadrature., such as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.

 
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> Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors

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