The present invention provides a hyperlipemia and/or hyperalbuminemia
animal model that is useful for the development of preventive/therapeutic
drugs for hyperlipemia and hyperalbuminemia, and in particular, that
develops hyperlipemia and hyperalbuminemia at the stage of senility
(advanced age) (in case of human, middle-aged and elderly). The
hyperlipemia and/or hyperalbuminemia animal model is obtained by raising
a transgenic rat (homozygote) into which a regucalcin gene is introduced
and which overexpresses regucalcin to the stage of senility (advanced
age), for example, 36 weeks of age, at which it exhibits symptoms of
hyperlipemia and/or hyperalbuminemia. This animal model exhibits not only
significant and marked increase of serum albumin, HDL-cholesterol and
triglyceride concentrations but also bone disorders.