Erythromycin A derivatives represented by the general formula ##STR00001## wherein R.sup.1 is a 2-alkenyl group having 3 to 15 carbon atoms, an arylmethyl group, or an arylmethyl group substituted by 1 to 3 of a halogen atom, an alkoxy group 1 to 4 carbon atoms, a nitro group or an alkoxycarbonyl group having 2 to 6 carbon atoms, R.sup.2 is a substituted silyl group and R.sup.3 is a hydrogen atom or R.sup.2, are disclosed. These compounds are useful as intermediates of the anti-bacterial agents.