Compounds are provided which are antagonists of chemokine receptor activity.The compounds thereof have the structure ##STR00001## including enantiomers, diastereomers, tautomers, pharmaceutically acceptable salts and solvates thereof wherein: A, B, D, E, X and Y are selected from N or C, J and K are C, and at least one of A, B, D, E, X and Y is N; L is selected from O, NH and S, wherein L may be connected to any one of A, B, D, E, J, X, K or Y; M is CH or N; P is a bond or C.dbd.O, wherein P is connected to any one of J, X, K or Y; Z is C(.dbd.O)GR.sup.2 or C(H).sub.2GR.sup.2; G is O or NH or none, or when Z is C(.dbd.O)GR.sup.2, G also includes 1, 2 propylene; n is 0 4; R.sup.1 is selected from halogen, --CN, --CF.sub.3, substituted alkyl, aryl and heteroaryl; R.sup.2 is a heterocyclyl containing at least one N; R.sup.3 is selected from halogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, wherein R.sup.3 is connected to any one of A, B, D and E; R.sup.4 and R.sup.5 are H; or R.sup.4 and R.sup.5 may be taken together with the atoms to which they are attached to form a ring; and R.sup.10 is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl; or E and R.sup.10 may be taken together with the atoms to which they are attached to form a heteroaryl or heterocycloalkyl ring.