A multi-position micro-fluidic valve system that includes an actuator assembly with a housing and a drive shaft rotatably disposed in the housing for rotational displacement about a drive axis thereof. One end of the drive shaft is configured to couple to a drive motor for selective rotation of the drive shaft about the drive axis. One of at least two different multi-position fluid valve devices can be removably mated to the actuator assembly. Each valve device is configured for rotational movement of a corresponding valve shaft about a valve rotational axis thereof between a plurality of discrete fluid distribution positions. A coupling device selectively and removably mounts the valve shaft of the respective valve device to the drive shaft of the actuator assembly. This enables selective positioning of the multi-position fluid valve device at a discrete one of the plurality for discrete distribution positions.