Compounds of formula (I) ##STR00001## wherein R is hydrogen, lower alkyl, (C.sub.3 C.sub.6)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted .beta.-naphthyl, bicyclic heterocyclic aryl, (C.sub.3 C.sub.6)cycloalkyl-monocyclic carbocyclic aryl, or (C.sub.5 or C.sub.6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.