A centrifugal processor is disclosed with includes an outer frame having an inner surface and an axis. At least one inner vessel positioned within the outer frame and is adapted to receive an object to be processed. A drive system rotate the inner vessel with respect to the outer frame and along the inner surface of the outer frame. The drive system includes a central shaft engaged with the vessel for rotating the vessel about the axis. An environmental control system is included which channels a secondary medium to or from the vessel to assist in the processing of the object. The environmental control system includes a manifold formed in at least a portion of the central shaft and adapted to channel the secondary medium. At least one port is formed in the central shaft and connected to the manifold. A conduit connects the port and the inner vessel for channeling the secondary medium between the manifold and the interior of the vessel.