The present invention provides a transformed silkworm which has a
polynucleotide encoding human collagen within the genomic DNA and
produces recombinant human collagen as a part of proteins in the cocoon
or the silk gland; a process for producing recombinant human collagen by
using this transformed silkworm; and a recombinant vector for use in the
generation of the transformed silkworm. Since human collagen is collected
from the cocoon discharged by this transformed silkworm or its silk
gland, highly pure human collagen can be conveniently obtained in a large
amount. Moreover, because the recombinant human collagen produced by the
transformed silkworm is safe collagen which is free from any fear of the
contamination with pathogens such as viruses or prions and exhibits no
antigenicity toward humans. Thus, it can be utilized in various
industrial fields including medicines, foods, cosmetics and the like.