The present invention provides novel compositions and methods for treating
symptoms associated with neuropathic disorders such as hyperalgesia,
allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane.
The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0]
hexanes in pharmaceutical compositions and methods for treating
neuropathic disorders and related symptoms in mammals. Patients amenable
to treatment according to the invention include those suffering from
diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia,
chronic lower back pain, sciatica, idiopathic and post-traumatic
neuropathies, HIV-associated neuropathic pain, among many other
neuropathic disorders and related symptoms.