This invention comprises the novel compounds of formula (I) wherein n, m, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine ##STR00001##

 
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> Histone deacetylase inhibitors based on trihalomethylcarbonyl compounds

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