The present invention relates to genetically engineered recombinant
respiratory syncytial viruses and viral vectors which contain deletions
of various viral accessory gene(s) either singly or in combination. In
accordance with the present invention, the recombinant respiratory
syncytial viral vectors and viruses are engineered to contain complete
deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various
combinations thereof. In addition, the present invention relates to the
attenuation of respiratory syncytial virus by mutagenisis of the M2-1
gene.