An analyte (e.g., glucose) is tested in a sample (e.g., blood or
blood-free interstitial fluid) having both the analyte and other
constituents (e.g., protein). The analyte has an absorption peak over a
narrow bandwidth at a characteristic wavelength. The other constituents
have an absorption over a broad bandwidth. The broad bandwidth includes
and is broader than the narrow bandwidth. Radiant energy (e.g., IR
radiation) is directed at the sample. The energy has a source bandwidth
including the broad bandwidth. The sample absorbs a portion of the
energy. A remainder of the energy is available for analysis. The
remainder is analyzed by filtering the remainder into an analyte portion
and a reference portion. The analyte portion contains substantially only
the narrow bandwidth. The reference portion contains substantially only
the broad bandwidth. The analyte portion and the reference portion are
measured and compared to calculate an amount of the analyte in the
sample.