A method for improving color-to-color registration in a printing device. The method includes printing a plurality of multi-color images, measuring the relative locations of a first portion of each multi-color image having a first color of each image and a second portion of each multi-color image having a second color of each image, for each image, comparing at least one difference between the first portion's location and the second portion's location with at least one desired difference between the first portion's location and the second portion's location to generate a list of positional errors, using a least square regression analysis of the list of positional errors to determine shift amounts required for placement of each first portion in subsequently generated images to within a desired degree of accuracy, and adjusting the placement of the first portion of each subsequently generated image by the determined shift amounts.