A system for permitting remotely located applications to obtain information about vehicle conditions and responsively perform programmatic actions based upon the vehicle conditions. The system can include a vehicle response server and a vehicle response agent. The vehicle response server can manage communications between one or more vehicles and at least one application remotely located from the vehicles. The application can automatically execute at least one context-dependent programmatic action based upon an event occurrence triggered by vehicle sensor input. The vehicle response agent, which resides within the vehicle can receive an activation context that specifies conditions for the event occurrence. The vehicle response agent can then monitor the vehicle for the event occurrence and, when appropriate, wirelessly convey an indication of the event occurrence to the vehicle response server. The indication can result in the automatic execution of the at least one context-dependent programmatic action.