A dynamically configurable threat scanning machine management system is capable of tracking information associated with one ore more items and/or passengers. The central control computer network can transmit, among other things, operational software and threat profiles to the threat scanning machines, while the threat scanning machines can transmit, among other things, images, alarms, and performance data to the central computer that can be distributed to one or more operator stations and/or other command and control centers for review and analysis. The threat scanning machine management system can be arranged in a hierarchical manner which enables threat scanning machines at various locations to be connected into regional, national or international control centers. The tracked information and alarm generation and distribution allow, for example, comparison to other information to determine if an alarm or change in thresholds or sensitivity is warranted.