Topical pain relief compositions of N,2,3-trimethyl-2-isopropylbutamide and methods for using the same are provided. The subject compositions include a pain relieving effective amount of N,2,3-trimethyl-2-isopropylbutamide in a topical formulation, e.g., a patch, gel, cream or foam. Also provided are methods of using the subject compositions in pain relief applications.