This invention provides transgenic mice carrying the humanized Hp-2 allele for haptoglobin. Specifically, provided herein are methods of the use of these transgenic mice in the diagnosis and rational drug design of compounds to be used in the treatment of vascular complications in diabetic subjects carrying the Hp-2 gene.

 
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> Transgenic animal having an amyloid precursor protein with a modified beta secretase cleavage site

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