A catheter apparatus is provided that includes a tubular body having a distal end. The body defines first and second lumens. The first lumen has a first adapter that includes a first valve biased to seal the proximal end. The first lumen defines a first lateral port and the second lumen defines a second lateral port. A push rod is connected to the first valve for corresponding movement therewith and extends to a tip. The tip includes a first member extending into the first lumen and a second member extending into the second lumen such that the first member seals the first lateral port and the second member seals the second lateral port in a closed position of the tip. The first valve is engageable such that fluid communication is established between the proximal end of the first lumen and the first lumen, and the first and second members move to an open position whereby fluid communication is established. The first and second lumens may be coaxial whereby the first lumen has a first port that seals a second port of the second lumen.

 
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> Macrolide analogs and methods for identifying same

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