A method of determining the voltage and current required for the
application of specific and selective electric and electromagnetic
signals to diseased articular cartilage in the treatment of
osteoarthritis, cartilage defects due to trauma or sports injury, or used
as an adjunct with other therapies (cell transplantation,
tissue-engineered scaffold, growth factors, etc.) for treating cartilage
defects in the human hip joint and a device for delivering such signals
to a patient's hip. Anatomic, analytical, and planar circuit models are
developed to determining the impedances, conductivities, and current
flows in the human hip joint and its surrounding soft tissues and skin
that are required to produce a 20 mV/cm electric field in the synovium
and articular cartilage of the human hip. The voltage of the signal
applied to the surface electrodes or to a coil(s) or solenoid is varied
based on the size of the hip joint; larger hip joints require larger
voltages to generate the effective electric field.