Various embodiments of an electrode array system and related methods are disclosed. The system may include a probe assembly having a plurality of probes configured to penetrate tissue of a patient and a guide assembly having a plurality of guiding channels. Each of the guiding channels may be configured to guide one or more of the plurality of probes to a desired tissue site. Some embodiments of an electrode array may include a housing and a plurality of probes extending from the housing. At least one of the plurality of probes may be individually deployable from the housing.