The invention relates to a double-stranded ribonucleic acid (dsRNA) for
inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an
antisense strand having a nucleotide sequence which is less that 25
nucleotides in length and which is substantially complementary to at
least a part of the Nav1.8 gene. The invention also relates to a
pharmaceutical composition comprising the dsRNA together with a
pharmaceutically acceptable carrier; methods for treating diseases caused
by the expression of the Nav1.8 gene using the pharmaceutical
composition; and methods for inhibiting the expression of the Nav1.8 gene
gene in a cell.