This invention provides a compound of the formula (I): ##STR00001##
wherein R.sup.1 represents a (C.sub.1 C.sub.6)alkyl group; R.sup.2
represents a hydrogen atom, a halogen atom, a hydroxy group, a (C.sub.1
C.sub.6)alkyl group or a (C.sub.1 C.sub.6)alkoxy group; R.sup.3, R.sup.4,
R.sup.5 and R.sup.6 each independently represents a hydrogen atom, a
(C.sub.1 C.sub.6)alkyl, or a halogen atom; R.sup.7 represents a hydrogen
atom, a halogen atom, a hydroxy group, a (C.sub.1 C.sub.6)alkyl group
optionally substituted with a piperidino group, a (C.sub.1 C.sub.6)alkoxy
group optionally substituted with a 3 7 membered cycloalkyl ring, a
hydroxy(C.sub.1 C.sub.6)alkoxy group, a (C.sub.1 C.sub.6)alkoxy-(C.sub.1
C.sub.6)alkyl group, a (C.sub.1 C.sub.6)alkoxy-(C.sub.1 C.sub.6)alkoxy
group, a halo (C.sub.1 C.sub.6)alkyl group, a (C.sub.1 C.sub.6)alkylthio
group, a (C.sub.1 C.sub.6)alkylsulfinyl group or a (C.sub.1
C.sub.6)alkylsulfonyl group; R.sup.8 represents a (C.sub.1 C.sub.6)alkyl
group, a halo(C.sub.1 C.sub.6)alkyl group, a (C.sub.1 C.sub.6)alkoxy
group, a hydroxy(C.sub.1 C.sub.6)alkoxy group, a (C.sub.1
C.sub.6)alkoxy-(C.sub.1 C.sub.6)alkyl group or a (C.sub.1
C.sub.6)alkoxy-(C.sub.1 C.sub.6)alkoxy group; or R.sup.7 and R.sup.8,
when adjacent to each other, taken together with the carbon atoms to
which they are attached form a 5 8 membered carbocyclic or heterocyclic
ring, wherein the carbocyclic ring or the heterocyclic ring is
unsubstituted or substituted with one or more substituents selected from
the group consisting of a hydroxy group, a (C.sub.1 C.sub.6)alkyl group,
a (C.sub.1 C.sub.6)alkoxy group and a hydroxy(C.sub.1 C.sub.6)alkyl
group; and R.sup.9 represents a hydrogen atom or a halogen atom; or a
pharmaceutically acceptable salt or solvate thereof.These compounds are
useful for the treatment of disease conditions caused by overactivation
of VR1 receptor, such as pain or the like in mammalian. The present
invention also provides a pharmaceutical composition comprising the
compound of formula(I).