A system and method are disclosed for performing dot inversion with standard drivers and backplane on novel display panel layouts. Suitable dot inversion schemes are implemented on a liquid crystal display having a panel and a driver circuit. The panel substantially comprises a subpixel repeating group, the group having a even number of subpixels across a first direction. The driver circuit comprises a set of drivers, coupled to the panel providing image data signals to the panel, the signals effecting substantially a dot inversion scheme to the panel. The drivers are also substantially connected to the columns of the panel in a sequence along the driver circuit wherein at least one driver is not connected to a column of the panel, and at least two subpixel regions of the panel having same colored subpixels in the two regions with substantially different polarities.