A class of imidazolyl compounds is described for use in treating
inflammation. Compounds of particular interest are defined by formula
(V), wherein R.sup.3 is a radical selected from hydrido, alkyl,
haloalkyl, aralkyl, heterocycloalkyl, heteroaralkyl, acyl, cyano, alkoxy,
alkylthio, alkylthioalkyl, alkylsulfonyl, cycloalkylthio,
cycloalkylthioalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl,
haloalkylsulfonyl, arylsulfonyl, halo, hydroxyalkyl, alkoxyalkyl,
alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclocarbonyl,
cyanoalkyl, aminoalkyl, alkylaminoalkyl, N-arylaminoalkyl,
N-alkyl-N-arylaminoalkyl, carboxyalkyl, alkoxy-carbonylalkyl,
alkoxycarbonyl, haloalkylcarbonyl, carboxyl, aminocarbonyl,
alkylaminocarbonyl, alkylaminocarbonylalkyl, heteroarylalkoxyalkyl,
heteroaryloxyalkyl, heteroarylthioalkyl, aralkoxy, aralkylthio,
heteroaralkoxy, heteroaralkylthio, heteroarylalkylthioalkyl,
heteroaryloxy, heteroarylthio, arylthioalkyl, aryloxyalkyl, arylthio,
aryloxy, aralkylthioalkyl, aralkoxyalkyl, aryl and heteroaryl; wherein
R.sup.4 is a radical selected from hydrido, alkyl and halo; and wherein
R.sup.13 and R.sup.14 are independently selected from aryl and
heterocyclo, wherein R.sup.13 and R.sup.14 are optionally substituted at
a substitutable position with one or more radicals independently selected
from alkylsulfonyl, aminosulfonyl, halo, alkylthio, alkyl, cyano,
carboxyl, alkoxycarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl,
alkoxyalkyl, haloalkoxy, amino, alkylamino, arylamino and nitro; provided
at least one of R.sup.13 and R.sup.14 is aryl substituted with
alkylsulfonyl or aminosulfonyl; or a pharmaceutically-acceptable salt
thereof ##STR00001##