The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof. wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen, halogen, C.sub.1-6-alkyl, C.sub.3-8-cycloalkyl, hydroxy, C.sub.1-6-alkoxy, C.sub.1-6-alkoxy-C.sub.1-6-alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C.sub.1-6-monoalkyl- or dialkylamino, sulfamoyl, C.sub.1-6-alkylthio, C.sub.1-6-alkylsulfonyl, C.sub.1-6-alkylsulfinyl, formyl, C.sub.1-6-alkylcarbonylamino, R.sub.8arylthio, R.sub.8arylsulfinyl, R.sub.8arylsulfonyl, C.sub.1-6-alkoxycarbonyl, C.sub.1-6-alkoxycarbonyl-C.sub.1-6-alkyl, carbamoyl, carbamoylmethyl, C.sub.1-6-monoalkyl- or dialkylaminocarbonyl, C.sub.1-6-monoalkyl- or dialkylaminothiocarbonyl, ureido, C.sub.1-6-monoalkyl- or dialkylaminocarbonylamino, thioureido, C.sub.1-6-monoalkyl- or dialkylaminothiocarbonylamino, C.sub.1-6-monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C.sub.1-6-alkyl, acyl, R.sub.8aryl, R.sub.8aryl-C.sub.1-6-alkyl, R.sub.8aryloxy; R.sub.5 and R.sub.6 are each independently hydrogen, C.sub.1-6-alkyl or, R.sub.5 and R.sub.6 taken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring; R.sub.7 is 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R.sub.1; R.sub.7 is 2- or 3-thienyl optionally mono- or polysubstituted substituted by R.sub.1 or R.sub.7 is phenyl optionally mono- or polysubstituted by R.sub.1 with the exception of or R.sub.7 representing C.sub.6H.sub.5; R.sub.8 is hydrogen, halogen, C.sub.1-6-alkyl, C.sub.3-8-cycloalkyl, hydroxy, C.sub.1-6-alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form.