An informatics system permits data entities from a wide range of data sources to be accessed and evaluated. The sources of the data entities may be simply data sources, such as for articles and other non-patient or population specific information, as well as controllable and prescribable sources, such diagnostic imaging, clinical and other sources forming part of the patient care path. The entities are organized, analyzed in accordance with a domain framework, which may be altered by a user to focus on factors and informational components of interest. Holistic and integrated understanding of such factors are there fore available, and refinement of healthcare processes can be made to provide improved care in a more time and cost effective manner.