The invention provides the compounds of formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof wherein: R.sup.0 and R.sup.1 are independently selected from the group consisting of H, halogen, C.sub.1-6alkyl, C.sub.1-6alkoxy, and C.sub.1-6alkoxy substituted by one or more fluorine atoms; R.sup.2 is selected from the group consisting of H, C.sub.1-6alkyl, C.sub.1-6alkyl substituted by one or more fluorine atoms, C.sub.1-6alkoxy, C.sub.1-6hydroxyalkyl, SC.sub.1-6alkyl, C(O)H, C(O)C.sub.1-6alkyl, C.sub.1-6alkylsulphonyl, and C.sub.1-6alkoxy substituted by one or more fluorine atoms; and R.sup.3 is C.sub.1-6alkyl or NH.sub.2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.