A compound of the formulae (I) or (II): ##STR00001## wherein: Y is a
moiety selected from NR or --(CH.sub.2).sub.n; wherein R is hydrogen or
(C.sub.1 C.sub.6) lower alkyl, and n is 1; ##STR00002## represents:
(1) a phenyl ring optionally substituted with one or two substituents
selected, independently, from the group comprising hydrogen, (C.sub.1
C.sub.6) lower alkyl, halogen, cyano, CF.sub.3, hydroxy, (C.sub.1
C.sub.6) lower alkoxy, (C.sub.1 C.sub.6) lower alkoxy carbonyl, carboxy,
--CONH.sub.2, --CONH[(C.sub.1 C.sub.6) lower alkyl], --CON[(C.sub.1
C.sub.6) lower alkyl].sub.2; or (2) a 6-membered aromatic (unsaturated)
heterocyclic ring having one nitrogen atom, optionally substituted by
(C.sub.1 C.sub.6) lower alkyl, halogen or (C.sub.1 C.sub.6) lower alkoxy;
##STR00003## represents: (1) a phenyl ring optionally substituted
with one or two substituents selected, independently, from the group
comprising hydrogen, (C.sub.1 C.sub.6) lower alkyl, halogen, cyano,
CF.sub.3, hydroxy, (C.sub.1 C.sub.6) lower alkoxy, or (C.sub.1 C.sub.6)
lower alkoxy carbonyl, carboxy, --CONH.sub.2, --CONH[(C.sub.1 C.sub.6)
lower alkyl], --CON[(C.sub.1 C.sub.6) lower alkyl].sub.2; or (2) a
5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen
atom, optionally substituted by (C.sub.1 C.sub.6) lower alkyl, (C.sub.1
C.sub.6) lower alkoxy, or halogen; or (3) a 6-membered aromatic
(unsaturated) heterocyclic ring having one nitrogen atom, optionally
substituted by (C.sub.1 C.sub.6) lower alkyl, halogen, or (C.sub.1
C.sub.6) lower alkoxy; ##STR00004## represents a 5-membered aromatic
(unsaturated) heterocyclic ring having one sulfur atom, optionally
substituted by (C.sub.1 C.sub.6) lower alkyl, halogen, or (C.sub.1
C.sub.6) lower alkoxy; R.sub.1 is a moiety of the formula
##STR00005## and R.sub.2, R.sub.3, R.sub.7, R.sub.8 and R.sub.9 are,
independently, selected from a group consisting of hydrogen, (C.sub.1
C.sub.3) lower alkyl, OCH.sub.3, halogen, CF.sub.3, --SCH.sub.3,
OCF.sub.3, SCF.sub.3, or CN; or a pharmaceutically acceptable salt, or
pro-drug form thereof.
