The present invention relates to compounds of formula (1): wherein X is
selected from hydrogen, a halogen, a substituted or unsubstituted cyclic
and heterocyclic moiety, substituted or unsubstituted, linear or branched
alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, alkenyl, alkenyloxy,
alkenylcarbonyl, alkenyloxycarbonyl, alkynyl, alkynyloxy,
alkynylcarbonyl, alkynyloxycarbonyl, aryl, benzyl, arlyoxy, arylcarbonyl,
aryloxycarbonyl and sulphur equivalents of said oxy, carbonyl and
oxycarbonyl moieties, R is selected from hydrogen, a halogen, an amide, a
substituted or unsubstituted cyclic and heterocyclic moiety, substituted
or unsubstituted, linear or branched alkyl, alkyloxy, alkylcarbonyl,
alkyloxycarbonyl, alkenyl, alkenyloxy, alkenylcarbonyl,
alkenyloxycarbonyl, alkynyl, alkynyloxy, alkynylcarbonyl,
alkynyloxycarbonyl, aryl, benzyl, arlyoxy, arylcarbonyl, aryloxycarbonyl
and sulphur equivalents of said oxy, carbonyl and oxycarbonyl moieties,
and R.sup.1 and R.sup.2 arc each independently selected from H,
C.sub.1-18 straight, branched or cyclic, saturated, unsaturated and
aromatic hydrocarbyl groups, which aromatic groups may be heterocyclic,
cyclic or acyclic and which may optionally be substituted by alkyl,
alkoxy, or halo; or R.sup.1 and R.sup.2, when taken together with the
N-atom to which they are bonded, may form an N-containing saturated,
unsaturated or partially unsaturated ring system comprising 3 to 10 ring
atoms selected from C, N and O, optionally substituted at any position of
the ring by a substituent selected from a halogen, a substituted or
unsubstituted cyclic and heterocyclic moiety, substituted or
unsubstituted, linear or branched alkyl, alkyloxy, alkylcarbonyl,
alkyloxycarbonyl, alkenyl, alkenyloxy, alkenylcarbonyl,
alkenyloxycarbonyl, alkynyl, alkynyloxy, alkynylcarbonyl,
alkynyloxycarbonyl, aryl, benzyl, arlyoxy, arylcarbonyl, aryloxycarbonyl,
sulphur equivalents of said oxy, carbonyl and oxycarbonyl moieties, and
oxo. The invention also relates to their uses as CCK receptor ligands and
CCK antagonists.