A system and method allows input/output to and from a computer system via the memory bus of a computer system. Input is accepted directly into shared memory or other memory and assigned to a processor or other entity. A processor or other entity may retrieve the input assigned to it and process the input. Output is written by the system processors to private memory, then retrieved from private memory by the system and method and output, for example to a network. Inputs and outputs are written to and from memory without using the I/O buses of the computer system and without generating interrupts to the system processors.