A drug dispenser 1 has a hollow body 2 with a housing 6 for a pressurised can 7 containing a drug and its propellant arranged on top of the body. The can has an outlet stem 8 received in a socket 9 in an internal spigot 10. This has a junction with a flexible tube 11, leading to a kink valve pair 12,14. The tube continues on to a second internal spigot 15, having a spray nozzle 16 just within a breathing opening 5. The kink valve pair 12, 14 is formed as a moulding of the tube, with side wings 17. Towards the ends of the wings, they have thinner portions 17.1 at which there are apertures 18 immediately adjacent the tube. The arrangement defines positions at which the tube kinks to close its through bore 19. The thinner portions are provided in two positions, which provide the two kink valves. An intermediate section 20 of the tube, with a predetermined volume is provided between the kink valves.