The invention provides antisense antiviral compounds and methods of their
use and production in inhibition of growth of viruses of the
Picornaviridae family and in the treatment of a viral infection. The
compounds are particularly useful in the treatment of Enterovirus and/or
Rhinovirus infection in a mammal. The antisense antiviral compounds are
substantially uncharged, including partially positively charged,
morpholino oligonucleotides have a sequence of 12-40 subunits, including
at least 12 subunits having a targeting sequence that is complementary to
a region associated with viral RNA sequences within a 32 nucleotide
region of the viral 5' untranslated region identified by SEQ ID NO:4.