A method and apparatus implementing an enhanced protocol between an I2C master and an I2C slave. In various embodiments the invention permits greater addressability space and high priority access to the slave device. The enhanced protocol is implemented by the addition of command code data being transmitted which is recognized through an interface circuit inside the slave device. The invention provides an I2C solution for accessing high priority address space with one command byte, medium priority space with two command bytes and low priority space with three command bytes.