A body bag is provided comprising a substantially planar, optically transparent envelope defining an interior and having an opening extending substantially along a length dimension thereof. A closure for sealing the opening is provided comprising a rib and groove structure and an adhesive flap for impermeably sealing the closure. Conveniently, the body bag envelope may be dimensioned to allow placement in an interior for a conventional body bag. At least one access means formed through the envelope material for accessing the interior of said envelope is provided, spaced along an opposite length dimension of the envelope from the opening. The access means may include unidirectional infusion or extraction ports, integral gloves for accessing the interior of the envelope, self-sealing injection ports, or combinations thereof. A second adhesive flap is provided for sealing the access means, thereby providing an impermeable seal of the envelope to prevent contamination of the environment with any hazardous contents of the envelope. The invention further provides a method for isolating a contaminated cadaver from contact with the environment.