The invention provides compositions and processes for the production of
ordered and repetitive antigen or antigenic determinant arrays. The
compositions of the invention are useful for the production of vaccines
for the prevention of infectious diseases, the treatment of allergies and
the treatment of cancers. Various embodiments of the invention provide
for a virus, virus-like particle, viral capsid particle, phage or
recombinant form thereof coated with any desired antigen in a highly
ordered and repetitive fashion as the result of specific interactions. In
one specific embodiment, a versatile new technology based on a
cassette-type system (AlphaVaccine Technology) allows production of
antigen coated viral particles. Other specific embodiments allow the
production of antigen coated hepatitis B virus-like particles or antigen
coated Measles virus-like particles.