A nonaqueous electrolyte secondary battery includes a positive electrode, a negative electrode comprising a graphite as a negative electrode active material, and a nonaqueous electrolyte including at least a saturated cyclic carbonic ester and containing a cyclic carbonic ester having a carbon-carbon double bond such that, when a content of the cyclic carbonic ester having a carbon-carbon double bond is x (g), a content of the graphite in the negative electrode is B (g), a specific surface area of the graphite is A (m.sup.2/g), a size of the crystallite of the graphite in a direction of the c axis is Lc, and a size of the crystallite of the graphite in a direction of the a axis is La, a condition expressed by 0.05.times.10.sup.-2.ltoreq.x/[A.times.B.times.2Lc/(2Lc+La)].ltoreq.3.tim- es.10.sup.-2 is satisfied.

 
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> Ion channel modulating compounds and uses thereof

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