The present invention provides methods of treating schizophrenia and/or
glucoregulatory abnormalities in a patient in need thereof comprising
administering to said patient a therapeutically effective amount of a
compound of formula I wherein in is 0, 1 or 2; n is 0, 1 or 2; p is 0 or
1; each R is independently hydrogen, halogen, trifluoromethyl,
C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6alkoxy, benzyloxy, hydroxy, nitro or
amino; each R.sub.1 is independently hydrogen, C.sub.1-C.sub.6alkyl,
C.sub.1-C.sub.6alkenyl, C.sub.1-C.sub.6alkanoyl, halogen, cyano,
--C(O)C.sub.1-C.sub.6alkyl, --C.sub.1-C.sub.6alkyleneCN,
--C.sub.1-C.sub.6alkyleneNR'R'' wherein R' and R'' are each independently
hydrogen or C.sub.1-C.sub.6alkyl,
--C.sub.1-C.sub.6alkyleneOC(O)C.sub.1-C.sub.6alkyl, or --CH(OH)R.sub.4
wherein R.sub.4 is hydrogen or C.sub.1-C.sub.6alkyl; R.sub.2 is
hydrogen, C.sub.1-C.sub.6alkyl optionally substituted with halogen,
hydroxy or benlzyloxy, C.sub.1-C.sub.6alkenyl, C.sub.1-C.sub.6alkynyl,
--CO.sub.2C.sub.1-C.sub.6alkyl, or --R.sub.5--NR'R'' wherein R.sub.5 is
C.sub.1-C.sub.6alkylene, C.sub.1-C.sub.6alkenylene or
C.sub.1-C.sub.6alkynylene and R' and R'' are each independently hydrogen,
C.sub.1-C.sub.6alkyl or alternatively the group --NR'R'' as a whole is
1-pyrrolidinyl; and R.sub.3 is hydrogen, nitro, amino, halogen,
C.sub.1-C.sub.6alkoxy, hydroxy or C.sub.1-C.sub.6alkyl or a
pharmaceutically acceptable salt thereof.