A system for opening and closing a resealable cartridge having a tray and a flexible cover resealably engaged with the tray. The system comprises: a base for receiving the tray of the cartridge; a roller shaft having means for engaging the cover of the cartridge; positioning means operably connected to the roller shaft to affect positioning of the roller shaft relative to the cartridge between a first position wherein the roller shaft is spaced from the cartridge and a second position different from the first position wherein the roller shaft is not spaced from the cartridge; and a motor for rotating the roller shaft in a first rotational direction to wind the cover about the roller shaft, thereby removing at least a portion of the cover from the tray, and for rotating the roller shaft in a second rotational direction to unwind the cover from the roller shaft thereby resealably engaging the cover with the tray.