Methods of treating a host suffering from restenosis are provided. The
methods include delivery of a stent coated with a hypoestoxide,
hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The
methods further include the administration of a chemotherapeutic agent in
combination with delivery of a stent coated with a hypoestoxide,
hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The
chemotherapeutic agent may be coated on the stent or administered
systemically.