A machine for the manufacture of flexible moulds is described, in particular for the obtainment of lipsticks or the like, which comprises a female mould including at least one moulding cavity fillable with a plastic fluid, a male mould including at least a male stem and means to insert said male stem into said cavity of the female mould after the same has been filled with said plastic fluid and to extract it from the same after a prefixed cooling period suitable to transform said fluid plastic into a flexible mould. In an embodiment thereof the machine comprises a revolving table in order to move in sequence said female mould and said male mould through a sequence of operating stations, a first station in which said plastic fluid is inserted into said cavity of the female mould while said male mould is removed from said female mould, a second station in which said male mould is brought near said female mould and locked on it so as to insert and to lock said male stem in said cavity filled with plastic fluid, a plurality of stations to cool said plastic fluid so as to transform it into a flexible mould, and a last station in which the male mould lifts up thus dragging with itself the flexible mould. An apparatus associated with said last station allows to pick up and to put in collection containers said flexible mould.