This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles in mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amounts of five NSAIDs and (ii) an amount effective in the treatment of muscle spasms of at least one of the muscle relaxants, wherein (iii) the said preparation is applied locally to muscles and optionally contains absorption and blood flow enhancers.