The present invention relates to therapeutically active and selective
inhibitors of the enzyme DPP-IV, which are of formula I ##STR00001##
wherein each n is one or two independently and R.sup.1, R.sup.2, R.sup.3,
R.sup.6, R.sup.7, R.sup.9, and R.sup.10 are defined herein. The present
invention also relates to pharmaceutical compositions comprising the
compounds of formula I and the use of the compounds for treating diseases
that are associated with proteins that are subject to inactivation by
DPP-IV, such as type-2 diabetes and obesity.