Therapeutically active thiazole derivatives of formula (I) wherein R.sup.1-R.sup.2, X and X' as are defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor .cndot. (TGF-.cndot.), and pharmaceutical compositions for use in such ##STR00001## therapy.