Trigger reception on different instrumentation devices may be synchronized by each instrumentation device generating one or more trigger enable signals and delaying performance of an operation in response to a trigger signal until a transition in a trigger enable signal. An instrumentation system may include several instrumentation devices and a communication medium coupling the instrumentation devices. One of the instrumentation devices may process data in response to a sample clock signal. That instrumentation device may also generate a trigger enable signal and delay performing an operation in response to a trigger signal transmitted via the communication medium until a transition in the trigger enable signal occurs. The trigger enable signal is not the sample clock signal. The trigger enable signal may be synchronized to another trigger enable signal generated by another one of the instrumentation devices.