Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable on-chip transponder. A power supply collects alternating current voltage pulses from an electro-active polymer generator embedded in muscle tissue for generating power for the on-chip transponder. The power supply is specifically adapted to provide a stable and precise sensor reference voltage to a sensor assembly to enhance the accuracy of measurements of a physiological parameter of a patient. The remote transponder receives data representative of the physiological parameter such as glucose concentration levels. The data is processed and transmitted to the remote transponder by the on-chip transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of a glucose sensor to allow for relatively accurate measurement of glucose concentration levels without the use of a microprocessor.