Disclosed herein are compositions and methods useful for the treatment of respiratory illness in a mammal, such as wherein these compositions and methods are effective in preventing the onset of one or more of the symptoms of such respiratory illness or significantly mitigating the symptom if the mammal is already afflicted with such symptom. The compositions used in the methods herein include a first component selected from the group consisting of andrographis extracts, active components thereof, and mixtures thereof, and a second component selected from the group consisting of turmeric extracts, active components thereof, and mixtures thereof.