An electrochemical sensor has a sensor housing and an ion-sensitive field effect transistor (ISFET) with a source connection (S) and a drain connection (D). An ion-sensitive surface area (IS) on the front surface of the ISFET is immersible in a measuring medium. A clamping element serves to clamp the ISFET with its rear surface against an end surface of the sensor housing. The clamping element has a central opening leaving the ion-sensitive surface area (IS) exposed. A leak-tight circular connection between the clamping element and the sensor housing is formed by vibratory, preferably ultrasonic, welding. The ISFET is sandwiched between two rubber-elastic elements, at least one of which forms a leak-tight seal against penetration of the measuring medium from the ion-sensitive surface area (IS) to the source- and drain connections (S) and (D).