The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. ##STR00001## In the formula, X represents 1) a C.sub.6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: ##STR00002## (in the above formulae, R.sup.y1, R.sup.y2 and R.sup.y3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, or a C.sub.3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: ##STR00003## (in the formula, m represents an integer of 0 to 2; R.sup.z1, R.sup.z2, R.sup.z3 and R.sup.z4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-7 cycloalkyl group, a halogenated C.sub.1-6 alkyl group, a halogenated C.sub.1-6 alkoxy group etc.); and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-7 cycloalkyl group etc.