A method of manufacturing an osteoinductive osteoimplant is provided which
comprises the steps of: demineralizing part or all of at least one
surface of a monolithic section of cortical bone to a depth of at least
about 100 microns; and, configuring the monolithic section of cortical
bone to provide an osteoimplant possessing an outer surface possessing at
least one demineralized zone and a non-demineralized zone. An implant
produced according to the above method demonstrates improved
osteoinduction without producing any clinically significant reduction of
strength in critical regions of the osteoimplant.